Specific interaction of oxidized low-density lipoprotein with thrombospondin-1 inhibits transforming growth factor-beta from its activation.

Sakamoto, Yu-ichiro; Miyazaki, Akira; Tamagawa, Harumi; Wang, Guo-Ping; Horiuchi, Seikoh

Sakamoto, Yu-ichiro; Miyazaki, Akira; Tamagawa, Harumi; Wang, Guo-Ping; Horiuchi, Seikoh.

Affiliation

Sakamoto Y; Department of Medical Biochemistry, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan. yusaka@kaiju.medic.kumamoto-u.ac.jp

Atherosclerosis ; 183(1): 85-93, 2005 Nov.

Article in En | MEDLINE | ID: mdl-15907858

Subject(s)

Lipoproteins, LDL/pharmacology; Macrophages, Peritoneal/drug effects; Thrombospondin 1/antagonists & inhibitors; Transforming Growth Factor beta/antagonists & inhibitors; Animals; Atherosclerosis/etiology; Blood Platelets/chemistry; Cell-Free System; Cells, Cultured/drug effects; Cells, Cultured/metabolism; Chromatography, Affinity; Culture Media/chemistry; Humans; Intracellular Signaling Peptides and Proteins/metabolism; Latent TGF-beta Binding Proteins; Lipoproteins, LDL/metabolism; Macrophages, Peritoneal/metabolism; Male; Mice; Protein Binding; Protein Interaction Mapping; Recombinant Proteins/metabolism; Thrombospondin 1/isolation & purification; Thrombospondin 1/metabolism; Transforming Growth Factor beta/metabolism; Transforming Growth Factor beta1

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Collection: 01-internacional Database: MEDLINE Main subject: Transforming Growth Factor beta / Macrophages, Peritoneal / Thrombospondin 1 / Lipoproteins, LDL Type of study: Etiology_studies Limits: Animals / Humans / Male Language: En Journal: Atherosclerosis Year: 2005 Document type: Article Affiliation country: Japan Country of publication: Ireland

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