Enhanced inhibition of transcription start by targeting with 2'-OMe pentaribonucleotides comprising locked nucleic acids and intercalating nucleic acids.

Filichev, Vyacheslav V; Vester, Birte; Hansen, Lykke H; Abdel Aal, Mohammed T; Babu, B Ravindra; Wengel, Jesper; Pedersen, Erik B

Filichev, Vyacheslav V; Vester, Birte; Hansen, Lykke H; Abdel Aal, Mohammed T; Babu, B Ravindra; Wengel, Jesper; Pedersen, Erik B.

Affiliation

Filichev VV; Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.

Chembiochem ; 6(7): 1181-4, 2005 Jul.

Article in En | MEDLINE | ID: mdl-15912554

Subject(s)

Oligonucleotides, Antisense/drug effects; Oligoribonucleotides/pharmacology; Transcription, Genetic/drug effects; Gene Expression/drug effects; Gene Expression/genetics; Humans; Nucleic Acid Conformation; Oligonucleotides; Oligonucleotides, Antisense/chemistry; Oligoribonucleotides/chemistry; Oligoribonucleotides/genetics; Transcription, Genetic/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Oligoribonucleotides / Transcription, Genetic / Oligonucleotides, Antisense Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2005 Document type: Article Affiliation country: Denmark

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