1H NMR study of the conformation and absolute stereochemistry of two spirocyclic NK-1 antagonists.

Herbert, Richard H; Gerhard, Ute; Mortishire-Smith, Russell J; Thomas, Steven R; Hollingworth, Gregory

Herbert, Richard H; Gerhard, Ute; Mortishire-Smith, Russell J; Thomas, Steven R; Hollingworth, Gregory.

Affiliation

Herbert RH; The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK.

Magn Reson Chem ; 43(8): 658-61, 2005 Aug.

Article in En | MEDLINE | ID: mdl-15924294

Subject(s)

Magnetic Resonance Spectroscopy/methods; Neurokinin-1 Receptor Antagonists; Spiro Compounds/chemistry; Crystallography, X-Ray; Magnetic Resonance Spectroscopy/standards; Models, Molecular; Molecular Conformation; Protons; Spiro Compounds/pharmacology; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Spiro Compounds / Magnetic Resonance Spectroscopy / Neurokinin-1 Receptor Antagonists Type of study: Prognostic_studies Language: En Journal: Magn Reson Chem Journal subject: QUIMICA Year: 2005 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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