Immune response and alteration of pulmonary function after primary human metapneumovirus (hMPV) infection of BALB/c mice.
Vaccine
; 23(36): 4473-80, 2005 Aug 22.
Article
in En
| MEDLINE
| ID: mdl-15927322
ABSTRACT
Human metapneumovirus (hMPV), a recently identified virus, causes upper and lower respiratory tract diseases. In this study, we show that BALB/c mice inoculated with hMPV exhibited significant morbidity on 1--2 days post-infection, when airway obstruction was found. Increased airway hyper-responsiveness to metacholine was found on day 4 concurrent with lung viral replication. Both IgG1 and IgG2a hMPV-specific antibodies were found in sera, while interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) were found in bronchoalveolar lavage. Lung histology showed parenchymal pneumonia and increased lymphocytic infiltration. We present here an animal model that may be helpful in studying hMPV pathogenesis and evaluating the effects of vaccines.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paramyxoviridae Infections
/
Metapneumovirus
/
Disease Models, Animal
/
Lung
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Vaccine
Year:
2005
Document type:
Article
Affiliation country:
France