Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.

Maring, Clarence J; Stoll, Vincent S; Zhao, Chen; Sun, Minghua; Krueger, Allan C; Stewart, Kent D; Madigan, Darold L; Kati, Warren M; Xu, Yibo; Carrick, Robert J; Montgomery, Debra A; Kempf-Grote, Anita; Marsh, Kennan C; Molla, Akhteruzzaman; Steffy, Kevin R; Sham, Hing L; Laver, W Graeme; Gu, Yu-gui; Kempf, Dale J; Kohlbrenner, William E

Maring, Clarence J; Stoll, Vincent S; Zhao, Chen; Sun, Minghua; Krueger, Allan C; Stewart, Kent D; Madigan, Darold L; Kati, Warren M; Xu, Yibo; Carrick, Robert J; Montgomery, Debra A; Kempf-Grote, Anita; Marsh, Kennan C; Molla, Akhteruzzaman; Steffy, Kevin R; Sham, Hing L; Laver, W Graeme; Gu, Yu-gui; Kempf, Dale J; Kohlbrenner, William E.

Affiliation

Maring CJ; Department of Infectious Disease Research and Advanced Technology, Global Pharmaceutical R & D, Abbott Laboratories, Abbott Park, Illinois 60064, USA. clarence.maring@abbott.com

J Med Chem ; 48(12): 3980-90, 2005 Jun 16.

Article in En | MEDLINE | ID: mdl-15943472

Subject(s)

Influenza A virus/enzymology; Influenza B virus/enzymology; Neuraminidase/antagonists & inhibitors; Neuraminidase/chemistry; Pyrrolidines/chemical synthesis; Animals; Binding Sites; Biological Availability; Crystallography, X-Ray; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Pyrrolidines/chemistry; Pyrrolidines/pharmacokinetics; Rats; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Influenza A virus / Influenza B virus / Pyrrolidines / Neuraminidase Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2005 Document type: Article Affiliation country: United States

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