Gender differences in the dihydropyrimidine dehydrogenase expression may contribute to higher toxicity in women treated with 5-fluorouracil therapy.

Altundag, Ozden; Altundag, Kadri; Silay, Kamile; Turen, Selahattin

Altundag, Ozden; Altundag, Kadri; Silay, Kamile; Turen, Selahattin.

Med Hypotheses ; 65(6): 1196, 2005.

Article in En | MEDLINE | ID: mdl-15951130

Subject(s)

Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP)/genetics; Drug-Related Side Effects and Adverse Reactions/epidemiology; Fluorouracil/therapeutic use; Neoplasms/drug therapy; Neoplasms/enzymology; Risk Assessment/methods; Antineoplastic Agents/therapeutic use; Clinical Trials as Topic; Female; Genetic Predisposition to Disease/epidemiology; Humans; Male; Neoplasms/epidemiology; Prevalence; Risk Factors; Sex Distribution; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Risk Assessment / Dihydrouracil Dehydrogenase (NADP) / Drug-Related Side Effects and Adverse Reactions / Dihydropyrimidine Dehydrogenase Deficiency / Fluorouracil / Neoplasms Type of study: Etiology_studies / Prevalence_studies / Risk_factors_studies Aspects: Determinantes_sociais_saude Limits: Female / Humans / Male Language: En Journal: Med Hypotheses Year: 2005 Document type: Article Country of publication: United States

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