Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons.

Dib-Hajj, S D; Rush, A M; Cummins, T R; Hisama, F M; Novella, S; Tyrrell, L; Marshall, L; Waxman, S G

Dib-Hajj, S D; Rush, A M; Cummins, T R; Hisama, F M; Novella, S; Tyrrell, L; Marshall, L; Waxman, S G.

Affiliation

Dib-Hajj SD; Department of Neurology, Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA.

Brain ; 128(Pt 8): 1847-54, 2005 Aug.

Article in En | MEDLINE | ID: mdl-15958509

Subject(s)

Erythromelalgia/genetics; Neurons, Afferent/physiology; Sodium Channels/genetics; Action Potentials/physiology; Adolescent; Adult; Aged; Base Sequence; Child; Child, Preschool; DNA/genetics; Erythromelalgia/physiopathology; Family Health; Female; Ganglia, Spinal/physiopathology; Humans; Male; Middle Aged; Mutation; NAV1.7 Voltage-Gated Sodium Channel; Nociceptors/physiopathology; Patch-Clamp Techniques/methods; Pedigree

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Collection: 01-internacional Database: MEDLINE Main subject: Sodium Channels / Erythromelalgia / Neurons, Afferent Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Language: En Journal: Brain Year: 2005 Document type: Article Affiliation country: United States Country of publication: United kingdom

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