Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists.

Röver, S; Adams, D R; Bénardeau, A; Bentley, J M; Bickerdike, M J; Bourson, A; Cliffe, I A; Coassolo, P; Davidson, J E P; Dourish, C T; Hebeisen, P; Kennett, G A; Knight, A R; Malcolm, C S; Mattei, P; Misra, A; Mizrahi, J; Muller, M; Porter, R H P; Richter, H; Taylor, S; Vickers, S P

Röver, S; Adams, D R; Bénardeau, A; Bentley, J M; Bickerdike, M J; Bourson, A; Cliffe, I A; Coassolo, P; Davidson, J E P; Dourish, C T; Hebeisen, P; Kennett, G A; Knight, A R; Malcolm, C S; Mattei, P; Misra, A; Mizrahi, J; Muller, M; Porter, R H P; Richter, H; Taylor, S; Vickers, S P.

Affiliation

Röver S; Vernalis Research Ltd., Oakdene Court, 613 Reading Road, Wokingham RG41 5UA, UK. stephan.roever@roche.com

Bioorg Med Chem Lett ; 15(15): 3604-8, 2005 Aug 01.

Article in En | MEDLINE | ID: mdl-15975787

Subject(s)

Eating/drug effects; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists/pharmacology; Animals; Indoles/chemical synthesis; Indoles/pharmacology; Injections, Subcutaneous; Pyrazines/chemical synthesis; Pyrazines/pharmacology; Pyridines/chemical synthesis; Pyridines/pharmacology; Rats; Rats, Wistar; Serotonin Receptor Agonists/chemical synthesis; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Serotonin Receptor Agonists / Eating / Serotonin 5-HT2 Receptor Agonists Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2005 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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