P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K.

Barrett, David G; Boncek, Virginia M; Catalano, John G; Deaton, David N; Hassell, Anne M; Jurgensen, Cynthia H; Long, Stacey T; McFadyen, Robert B; Miller, Aaron B; Miller, Larry R; Payne, J Alan; Ray, John A; Samano, Vicente; Shewchuk, Lisa M; Tavares, Francis X; Wells-Knecht, Kevin J; Willard, Derril H; Wright, Lois L; Zhou, Hui-Qiang Q

Barrett, David G; Boncek, Virginia M; Catalano, John G; Deaton, David N; Hassell, Anne M; Jurgensen, Cynthia H; Long, Stacey T; McFadyen, Robert B; Miller, Aaron B; Miller, Larry R; Payne, J Alan; Ray, John A; Samano, Vicente; Shewchuk, Lisa M; Tavares, Francis X; Wells-Knecht, Kevin J; Willard, Derril H; Wright, Lois L; Zhou, Hui-Qiang Q.

Affiliation

Barrett DG; Department of Medicinal Chemistry, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.

Bioorg Med Chem Lett ; 15(15): 3540-6, 2005 Aug 01.

Article in En | MEDLINE | ID: mdl-15982880

Subject(s)

Amides/chemical synthesis; Cathepsins/antagonists & inhibitors; Cysteine Proteinase Inhibitors/chemical synthesis; Ketones/chemical synthesis; Amides/pharmacokinetics; Amides/pharmacology; Animals; Binding Sites; Biological Availability; Bone Resorption/drug therapy; Bone Resorption/metabolism; Cathepsin K; Cathepsins/chemistry; Cysteine Proteinase Inhibitors/pharmacokinetics; Cysteine Proteinase Inhibitors/pharmacology; Disease Models, Animal; Hypocalcemia/drug therapy; Hypocalcemia/metabolism; Ketones/pharmacokinetics; Ketones/pharmacology; Rats; Rats, Wistar; Solubility; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Cathepsins / Cysteine Proteinase Inhibitors / Amides / Ketones Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2005 Document type: Article Affiliation country: United States Country of publication: United kingdom

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