Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritis.

Yudoh, Kazuo; Nakamura, Hiroshi; Masuko-Hongo, Kayo; Kato, Tomohiro; Nishioka, Kusuki

Yudoh, Kazuo; Nakamura, Hiroshi; Masuko-Hongo, Kayo; Kato, Tomohiro; Nishioka, Kusuki.

Affiliation

Yudoh K; Department of Bioregulation, Institute of Medical Science, St, Marianna University School of Medicine, Kawasaki, Japan. yudo@marianna-u.ac.jp

Arthritis Res Ther ; 7(4): R904-14, 2005.

Article in En | MEDLINE | ID: mdl-15987493

Subject(s)

Cartilage, Articular/metabolism; Chondrocytes/metabolism; Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis; Osteoarthritis, Knee/etiology; Osteoarthritis, Knee/metabolism; Oxidative Stress/physiology; Aged; Cartilage, Articular/cytology; Cartilage, Articular/drug effects; Cells, Cultured; Chondrocytes/drug effects; Enzyme Inhibitors/pharmacology; Female; Gene Expression Regulation/drug effects; Gene Expression Regulation/physiology; Humans; Hydrogen Peroxide/toxicity; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Interleukin-1/toxicity; Male; Middle Aged; Osteoarthritis, Knee/genetics; Oxidative Stress/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cartilage, Articular / Oxidative Stress / Chondrocytes / Osteoarthritis, Knee / Hypoxia-Inducible Factor 1, alpha Subunit Type of study: Etiology_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Arthritis Res Ther Journal subject: REUMATOLOGIA Year: 2005 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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