Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock.

Hu, Jialiang; Van den Steen, Philippe E; Dillen, Chris; Opdenakker, Ghislain

Hu, Jialiang; Van den Steen, Philippe E; Dillen, Chris; Opdenakker, Ghislain.

Affiliation

Hu J; Rega Institute for Medical Research, Laboratory of Immunobiology, University of Leuven, Minderbroedersstraat 10, Leuven 3000, Belgium.

Biochem Pharmacol ; 70(4): 535-44, 2005 Aug 15.

Article in En | MEDLINE | ID: mdl-15992779

Subject(s)

Endotoxins/toxicity; Matrix Metalloproteinase 8/metabolism; Matrix Metalloproteinase 9/metabolism; Oligopeptides/pharmacology; Protease Inhibitors/pharmacology; Animals; Half-Life; Humans; Mice; Molecular Mimicry; Protease Inhibitors/blood; Protease Inhibitors/pharmacokinetics

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Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Protease Inhibitors / Matrix Metalloproteinase 9 / Matrix Metalloproteinase 8 / Endotoxins Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2005 Document type: Article Affiliation country: Belgium Country of publication: United kingdom

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