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Rhinovirus viremia in children with respiratory infections.
Xatzipsalti, Maria; Kyrana, Serena; Tsolia, Mariza; Psarras, Stelios; Bossios, Apostolos; Laza-Stanca, Vasile; Johnston, Sebastian L; Papadopoulos, Nikolaos G.
Affiliation
  • Xatzipsalti M; Allergy Department, Second Pediatric Clinic, University of Athens, Athens, Greece.
Am J Respir Crit Care Med ; 172(8): 1037-40, 2005 Oct 15.
Article in En | MEDLINE | ID: mdl-15994468
RATIONALE: Viremia has been implicated in many viral infections; however, viremia due to rhinovirus (RV; rhinoviremia) has been considered not to occur in normal individuals. OBJECTIVE: To evaluate whether RV enters the bloodstream and identify the possible risk factors. METHODS: Nasopharyngeal washes (NPWs) of 221 children with respiratory infections were examined for the presence of RV by reverse transcription-polymerase chain reaction. Blood from 88 children, whose NPW was RV-positive, and 31 of RV-negative control subjects was subsequently examined for the presence of RV in the blood by semi-nested reverse transcription-polymerase chain reaction. Rhinoviremia was then correlated with clinical characteristics of the disease. RESULTS: RV was detected in the blood of 10 out of 88 NPW RV-positive cases (11.4%): 7 of 28 children with asthma exacerbations (25.0%), 2 of 26 with common cold (7.7%), 1 of 25 with bronchiolitis (4.0%), and 0 of 9 with pneumonia (0%). All NPW RV-negative cases were negative in the blood. The proportion of rhinoviremia in children with asthma exacerbation was significantly higher compared with children suffering from the other diseases (25 vs. 5%, p = 0.01). Significant risk factors were: sampling
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Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia, Viral / Asthma / Rhinovirus / Viremia / Bronchiolitis / Common Cold Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Europa Language: En Journal: Am J Respir Crit Care Med Journal subject: TERAPIA INTENSIVA Year: 2005 Document type: Article Affiliation country: Greece Country of publication: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia, Viral / Asthma / Rhinovirus / Viremia / Bronchiolitis / Common Cold Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Europa Language: En Journal: Am J Respir Crit Care Med Journal subject: TERAPIA INTENSIVA Year: 2005 Document type: Article Affiliation country: Greece Country of publication: United States