Complete rescue of lipoprotein lipase-deficient mice by somatic gene transfer of the naturally occurring LPLS447X beneficial mutation.

Ross, Colin J D; Liu, Guoqing; Kuivenhoven, Jan Albert; Twisk, Jaap; Rip, Jaap; van Dop, Willemijn; Excoffon, Katherine J D Ashbourne; Lewis, Suzanne M E; Kastelein, John J; Hayden, Michael R

Ross, Colin J D; Liu, Guoqing; Kuivenhoven, Jan Albert; Twisk, Jaap; Rip, Jaap; van Dop, Willemijn; Excoffon, Katherine J D Ashbourne; Lewis, Suzanne M E; Kastelein, John J; Hayden, Michael R.

Affiliation

Ross CJ; Department of Medical Genetics, University of British Columbia, Centre for Molecular Medicine and Therapeutics, Vancouver, Canada.

Arterioscler Thromb Vasc Biol ; 25(10): 2143-50, 2005 Oct.

Article in En | MEDLINE | ID: mdl-16002740

Subject(s)

Genetic Therapy/methods; Hypertriglyceridemia/therapy; Lipoprotein Lipase/genetics; Lipoprotein Lipase/metabolism; Point Mutation; Adenoviridae/genetics; Animals; Animals, Newborn; CHO Cells; Cholesterol, HDL/blood; Cricetinae; Fertility; Gene Transfer Techniques; Humans; Hypertriglyceridemia/blood; Hypertriglyceridemia/genetics; Lactation; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; RNA, Messenger/analysis; Triglycerides/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Hypertriglyceridemia / Point Mutation / Lipoprotein Lipase Limits: Animals / Humans Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2005 Document type: Article Affiliation country: Canada

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