Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.

Inagaki, Yutaka; Kushida, Miwa; Higashi, Kiyoshi; Itoh, Johbu; Higashiyama, Reiichi; Hong, Yun Yu; Kawada, Norifumi; Namikawa, Kazuhiko; Kiyama, Hiroshi; Bou-Gharios, George; Watanabe, Tetsu; Okazaki, Isao; Ikeda, Kazuo

Inagaki, Yutaka; Kushida, Miwa; Higashi, Kiyoshi; Itoh, Johbu; Higashiyama, Reiichi; Hong, Yun Yu; Kawada, Norifumi; Namikawa, Kazuhiko; Kiyama, Hiroshi; Bou-Gharios, George; Watanabe, Tetsu; Okazaki, Isao; Ikeda, Kazuo.

Affiliation

Inagaki Y; Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan. yutakai@is.icc.u-tokai.ac.jp

Gastroenterology ; 129(1): 259-68, 2005 Jul.

Article in En | MEDLINE | ID: mdl-16012952

Subject(s)

Collagen/genetics; DNA-Binding Proteins/metabolism; Genetic Therapy/methods; Liver Cirrhosis/physiopathology; Liver Cirrhosis/therapy; Trans-Activators/metabolism; Transforming Growth Factor beta/metabolism; Adenoviridae/genetics; Animals; Carbon Tetrachloride; Collagen Type I; DNA-Binding Proteins/genetics; Enhancer Elements, Genetic/physiology; Gene Expression/physiology; Green Fluorescent Proteins/genetics; Interferon-gamma/metabolism; Liver Cirrhosis/pathology; Mice; Mice, Transgenic; Nuclear Proteins; Promoter Regions, Genetic/physiology; Rats; Signal Transduction/physiology; Smad Proteins; Y-Box-Binding Protein 1

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Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Trans-Activators / Transforming Growth Factor beta / Collagen / DNA-Binding Proteins / Liver Cirrhosis Limits: Animals Language: En Journal: Gastroenterology Year: 2005 Document type: Article Affiliation country: Japan Country of publication: United States

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