Distributed neural actions of anti-parkinsonian therapies as revealed by PET.
J Neural Transm (Vienna)
; 113(1): 75-86, 2006 Jan.
Article
in En
| MEDLINE
| ID: mdl-16049638
ABSTRACT
There is a limited understanding of how different anti-parkinsonian treatments act at the neuronal systems level. Using positron emission tomography we examined the effects of levodopa and deep brain stimulation of the subthalamic nucleus on patterns of regional cerebral blood flow in patients with Parkinson's disease during a homogenous cognitive-behavioural state rather than during an unspecified resting state. We found that when medicated precuneus, frontal, parietal, cerebellar and midbrain areas were relatively more activated than when stimulated, whereas when stimulated the precentral gyrus, caudate and thalamus were relatively more activated than when medicated. Areas that were activated by both treatments included the temporal gyri, anterior thalamus, and midbrain. Regions of prefrontal cortex showed relatively greater activation in the "off treatment" conditions of both the medicated and stimulated groups. Our findings suggest that the two treatment methods may lead to symptomatic relief via both common and different sites of action.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Brain
/
Positron-Emission Tomography
/
Deep Brain Stimulation
/
Antiparkinson Agents
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Humans
/
Middle aged
Language:
En
Journal:
J Neural Transm (Vienna)
Year:
2006
Document type:
Article
Affiliation country:
United kingdom