Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1.

Green, B D; Liu, H K; McCluskey, J T; Duffy, N A; O'Harte, F P M; McClenaghan, N H; Flatt, P R

Green, B D; Liu, H K; McCluskey, J T; Duffy, N A; O'Harte, F P M; McClenaghan, N H; Flatt, P R.

Affiliation

Green BD; School of Biomedical Sciences, University of Ulster, Coleraine, N. Ireland, UK. b.green@ulster.ac.uk

Diabetes Obes Metab ; 7(5): 563-9, 2005 Sep.

Article in En | MEDLINE | ID: mdl-16050949

Subject(s)

Dipeptidyl Peptidase 4/physiology; Glucagon-Like Peptide 1/pharmacology; Insulin-Secreting Cells/drug effects; Insulin/metabolism; Animals; Cell Division/drug effects; Cell Line; Dipeptidyl Peptidase 4/metabolism; Dose-Response Relationship, Drug; Glucagon-Like Peptide 1/metabolism; Insulin-Secreting Cells/cytology; Insulin-Secreting Cells/metabolism; Oligopeptides/pharmacology; Protease Inhibitors/pharmacology; Rats

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Collection: 01-internacional Database: MEDLINE Main subject: Dipeptidyl Peptidase 4 / Insulin-Secreting Cells / Glucagon-Like Peptide 1 / Insulin Limits: Animals Language: En Journal: Diabetes Obes Metab Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2005 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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