An S101P substitution in the putative cleavage motif of the human metapneumovirus fusion protein is a major determinant for trypsin-independent growth in vero cells and does not alter tissue tropism in hamsters.

Schickli, Jeanne H; Kaur, Jasmine; Ulbrandt, Nancy; Spaete, Richard R; Tang, Roderick S

Schickli, Jeanne H; Kaur, Jasmine; Ulbrandt, Nancy; Spaete, Richard R; Tang, Roderick S.

Affiliation

Schickli JH; MedImmune Vaccines, Inc., 297 N. Bernardo Ave., Mountain View, CA 94043, USA. schicklij@medimmune.com

J Virol ; 79(16): 10678-89, 2005 Aug.

Article in En | MEDLINE | ID: mdl-16051860

Subject(s)

Metapneumovirus/growth & development; Trypsin/pharmacology; Viral Fusion Proteins/physiology; Amino Acid Motifs; Amino Acid Sequence; Animals; Chlorocebus aethiops; Cricetinae; Mesocricetus; Molecular Sequence Data; Tropism; Vero Cells; Viral Fusion Proteins/chemistry; Virus Replication

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypsin / Viral Fusion Proteins / Metapneumovirus Limits: Animals Language: En Journal: J Virol Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google