Therapeutic vaccination with papillomavirus E6 and E7 long peptides results in the control of both established virus-induced lesions and latently infected sites in a pre-clinical cottontail rabbit papillomavirus model.
Vaccine
; 23(45): 5271-80, 2005 Nov 01.
Article
in En
| MEDLINE
| ID: mdl-16054734
ABSTRACT
This study was performed to test the therapeutic efficacy of overlapping long E6 and E7 peptides, containing both CD4+ T-helper and CD8+ CTL epitopes, on CRPV-induced lesions, which is an appropriate pre-clinical model for HPV diseases, including recurrent respiratory papillomatosis (RRP). Therapeutic peptide vaccination was able to significantly control wart growth (p < 0.01) and abrogate latent CRPV infection (p = 0.0006) compared to controls. Vaccination was associated with a T(H)1 T cell response, as suggested by a strong DTH skin test, antigen-specific proliferation of PBMC and a minimal IgG antibody response. Thus, this study shows promise for treatment of RRP by vaccination with long peptides.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tumor Virus Infections
/
Oncogene Proteins, Viral
/
Cottontail rabbit papillomavirus
Limits:
Animals
Language:
En
Journal:
Vaccine
Year:
2005
Document type:
Article
Affiliation country:
United States