[Effect of hypoxia on the expression of urokinase-type plasminogen activator in human tongue squamous cell carcinoma cells (Tca8113)].
Hua Xi Kou Qiang Yi Xue Za Zhi
; 23(3): 211-3, 2005 Jun.
Article
in Zh
| MEDLINE
| ID: mdl-16078458
ABSTRACT
OBJECTIVE:
To observe the expression of urokinase-type plasminogen activator (uPA) in human tongue squamous carcinoma cells (Tca8113) under hypoxia, in order to explore the relation between hypoxia and invasion and metastasis of oral cancer.METHODS:
Under different hypoxic times(0, 3, 6, 12, 24 h), the expression of uPA protein was examined quantitatively using immunohistochemical technique (IH) and flow cytometry (FCM).RESULTS:
Hypoxia promoted the expression of uPA. The longer hypoxic time was, the higher expression of uPA was.CONCLUSION:
Hypoxia can promote invasion and metastasis of oral squamous carcinoma through stimulating the expression of uPA.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urokinase-Type Plasminogen Activator
/
Neoplasm Invasiveness
Limits:
Humans
Language:
Zh
Journal:
Hua Xi Kou Qiang Yi Xue Za Zhi
Journal subject:
ODONTOLOGIA
Year:
2005
Document type:
Article
Affiliation country:
China