Enantioselective total synthesis of (-)-candelalide A, a novel blocker of the voltage-gated potassium channel Kv1.3 for an immunosuppressive agent.
Org Lett
; 7(17): 3745-8, 2005 Aug 18.
Article
in En
| MEDLINE
| ID: mdl-16092865
ABSTRACT
A convergent route to (-)-candelalide A involved the union of a trans-decalin portion (AB ring) and a gamma-pyrone moiety through the C16-C3' bond to assemble the whole carbon framework and subsequent formation of the dihydropyran ring (C ring) as the crucial steps. A strategic [2,3]-Wittig rearrangement was employed for establishing the stereogenic center at C9 and an exo-methylene function at C8 present in the decalin portion. [reaction see text]
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrones
/
Diterpenes
/
Kv1.3 Potassium Channel
/
Immunosuppressive Agents
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2005
Document type:
Article
Affiliation country:
Japan