Enhanced in vitro percutaneous absorption and in vivo anti-inflammatory effect of a selective cyclooxygenase inhibitor using microemulsion.

Subramanian, N; Ghosal, Saroj K; Moulik, S P

Subramanian, N; Ghosal, Saroj K; Moulik, S P.

Affiliation

Subramanian N; Deparment of Pharmaceutical Engineering and Technology, School of Engineering and Technology, Bharathidasan University, Trichy, India.

Drug Dev Ind Pharm ; 31(4-5): 405-16, 2005 May.

Article in En | MEDLINE | ID: mdl-16093206

Subject(s)

Anti-Inflammatory Agents/pharmacokinetics; Cyclooxygenase Inhibitors/pharmacokinetics; Inflammation/prevention & control; Skin Absorption; Skin/metabolism; Administration, Cutaneous; Animals; Anti-Inflammatory Agents/administration & dosage; Anti-Inflammatory Agents/chemistry; Celecoxib; Cyclooxygenase Inhibitors/administration & dosage; Cyclooxygenase Inhibitors/chemistry; Drug Stability; Emulsions; Glycerides/administration & dosage; Glycerides/chemistry; Glycerides/pharmacokinetics; In Vitro Techniques; Inflammation/chemically induced; Male; Mice; Myristates/chemistry; Oils/chemistry; Permeability; Polysorbates/chemistry; Pyrazoles/administration & dosage; Pyrazoles/chemistry; Pyrazoles/pharmacokinetics; Rats; Rats, Sprague-Dawley; Skin/pathology; Solubility; Sulfonamides/administration & dosage; Sulfonamides/chemistry; Sulfonamides/pharmacokinetics

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Collection: 01-internacional Database: MEDLINE Main subject: Skin / Skin Absorption / Cyclooxygenase Inhibitors / Inflammation / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Drug Dev Ind Pharm Year: 2005 Document type: Article Affiliation country: India Country of publication: United kingdom

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