Colorectal cancer: mutations in a signalling pathway.
Nature
; 436(7052): 792, 2005 Aug 11.
Article
in En
| MEDLINE
| ID: mdl-16094359
ABSTRACT
Protein kinases are enzymes that are important for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Colorectal Neoplasms
/
Signal Transduction
/
Mutation
Limits:
Humans
Language:
En
Journal:
Nature
Year:
2005
Document type:
Article
Affiliation country:
United States