Inflammation and neurogenesis in temporal lobe epilepsy.
Curr Drug Targets CNS Neurol Disord
; 4(4): 349-60, 2005 Aug.
Article
in En
| MEDLINE
| ID: mdl-16101554
ABSTRACT
The aim of the present review is to discuss the evidence supporting the hypothesis that inflammation and neurogenesis play an important role in temporal lobe epilepsy (TLE) and to examine whether possible strategies that involve the pharmacological manipulation of inflammation/neurogenesis can lead to the development of novel approaches for the treatment of epilepsy. Since it is not yet clear whether the neuron-glia response obtained in this pathology is a secondary effect of an aggressive inflammation or if it is somehow related to the cause of the epileptic condition, with the present review we guide the readers through the complex and ambiguous crosstalk between neuroimmunology and epilepsy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Differentiation
/
Cytokines
/
Epilepsy, Temporal Lobe
/
Kindling, Neurologic
/
Neurons
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Drug Targets CNS Neurol Disord
Journal subject:
NEUROLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2005
Document type:
Article
Affiliation country:
Portugal