Characterization and quantification of Bcl-2 antisense G3139 and metabolites in plasma and urine by ion-pair reversed phase HPLC coupled with electrospray ion-trap mass spectrometry.

Dai, Guowei; Wei, Xiaohui; Liu, Zhongfa; Liu, Shujun; Marcucci, Guido; Chan, Kenneth K

Dai, Guowei; Wei, Xiaohui; Liu, Zhongfa; Liu, Shujun; Marcucci, Guido; Chan, Kenneth K.

Affiliation

Dai G; Division of Pharmaceutics, College of Pharmacy, Room no. 308, The Ohio State University, Comprehensive Cancer Center (OSU CCC), 410 W12th Ave., Columbus, OH 43210, USA.

J Chromatogr B Analyt Technol Biomed Life Sci ; 825(2): 201-13, 2005 Oct 25.

Article in En | MEDLINE | ID: mdl-16111926

Subject(s)

Chromatography, High Pressure Liquid/methods; Oligonucleotides, Antisense/blood; Oligonucleotides, Antisense/urine; Spectrometry, Mass, Electrospray Ionization/methods; Thionucleotides/blood; Thionucleotides/urine; Animals; Base Sequence; Female; Humans; Ions; Rats; Rats, Sprague-Dawley; Thionucleotides/pharmacokinetics

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Collection: 01-internacional Database: MEDLINE Main subject: Thionucleotides / Chromatography, High Pressure Liquid / Oligonucleotides, Antisense / Spectrometry, Mass, Electrospray Ionization Limits: Animals / Female / Humans Language: En Journal: J Chromatogr B Analyt Technol Biomed Life Sci Journal subject: ENGENHARIA BIOMEDICA Year: 2005 Document type: Article Affiliation country: United States

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