[Chromosomal aberrations in myelodysplastic syndrome].
Ter Arkh
; 77(7): 27-33, 2005.
Article
in Ru
| MEDLINE
| ID: mdl-16116905
ABSTRACT
AIM:
To analyse incidence rate of chromosomal aberrations in myelodysplastic syndromes (MDS), specification of clinicomorphological features of some cytogenetic variants. MATERIAL ANDMETHODS:
Chromosomal analysis by the method of G-differential staining of chromosomes was made in 209 patients with different variants of MDS. RESULTS; Clonal chromosomal aberrations occured in 60.8%. The following aberrations were found most frequently deletion of the long arm of the chromosome 5 (del(5q)) - 34.6%, trisomy of chromosome 8 (14.1%), monosomy of chromosome 7 (13.4%), aberrations 3q21q26 (12.6%), aberrations of a long arm of X-chromosome (4.7%), the absence of Y-chromosome (3.1%). Complex aberrations of karyotype were found in 13.5% cases. Chromosomal aberrations determined not only clinical and morphological features but also the prognosis of the disease.CONCLUSION:
Cytogenetic examination is an essential component of MDS patients examination. It allows more precise classification of MDS variant and prognostification of the disease course.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Myelodysplastic Syndromes
/
Chromosomes, Human, Pair 5
/
Chromosomes, Human, Pair 7
/
Chromosomes, Human, Pair 8
/
Chromosome Aberrations
/
Chromosomes, Human, X
/
Chromosomes, Human, Y
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Ru
Journal:
Ter Arkh
Year:
2005
Document type:
Article