Plasmid-based growth hormone-releasing hormone supplementation and its applications.
Curr Opin Mol Ther
; 7(4): 306-16, 2005 Aug.
Article
in En
| MEDLINE
| ID: mdl-16121696
ABSTRACT
A single dose of a plasmid expressing growth hormone-releasing hormone (GHRH) has been safely used in a number of animal species and applications to physiologically increase growth hormone and insulin-like growth factor-I for over a year. An array of constructs encoding for analogs of, or species-specific, GHRH has been tested to treat anemia and cachexia associated with cancer and its treatment, and renal failure, as well as to increase immune surveillance and animal welfare. The positive results obtained with plasmid-based GHRH in companion and farm animals may be translated to a number of human applications.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasmids
/
Genetic Therapy
/
Growth Hormone-Releasing Hormone
/
Genetic Vectors
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Mol Ther
Journal subject:
BIOLOGIA MOLECULAR
/
TERAPEUTICA
Year:
2005
Document type:
Article
Affiliation country:
United States