Successful use of the new immune-suppressor sirolimus in IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome).
J Pediatr
; 147(2): 256-9, 2005 Aug.
Article
in En
| MEDLINE
| ID: mdl-16126062
ABSTRACT
IPEX (immune-dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome is an autoimmune disorder with an often lethal outcome in spite of immunosuppressive therapy. We report the successful use of sirolimus in 3 patients with IPEX. The efficacy of sirolimus is probably due to its different mode of action compared to calcineurin-dependent agents.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyendocrinopathies, Autoimmune
/
Sirolimus
/
Immunosuppressive Agents
Limits:
Child
/
Humans
/
Male
Language:
En
Journal:
J Pediatr
Year:
2005
Document type:
Article
Affiliation country:
Germany