Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor.

Hirschfeld, J; Buschauer, A; Elz, S; Schunack, W; Ruat, M; Traiffort, E; Schwartz, J C

Hirschfeld, J; Buschauer, A; Elz, S; Schunack, W; Ruat, M; Traiffort, E; Schwartz, J C.

Affiliation

Hirschfeld J; Institute of Pharmacy, Freie Universität Berlin, Germany.

J Med Chem ; 35(12): 2231-8, 1992 Jun 12.

Article in En | MEDLINE | ID: mdl-1613748

Subject(s)

Azides/chemical synthesis; Guanidines/chemical synthesis; Aniline Compounds/chemistry; Animals; Atrial Function; Azides/metabolism; Azides/pharmacology; Guanidines/metabolism; Guanidines/pharmacology; Guinea Pigs; Heart Atria/drug effects; Heart Rate/drug effects; Iodine Radioisotopes; Male; Muscle Contraction/drug effects; Receptors, Histamine H2/metabolism; Structure-Activity Relationship; Sulfonamides/chemical synthesis; Sulfonamides/metabolism; Sulfonamides/pharmacology; Vasoconstriction/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Azides / Guanidines Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1992 Document type: Article Affiliation country: Germany Country of publication: United States

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