Clinical and immunological responses to undiluted and diluted smallpox vaccine with vaccinia virus of Lister strain.
Vaccine
; 24(4): 510-5, 2006 Jan 23.
Article
in En
| MEDLINE
| ID: mdl-16139395
ABSTRACT
The potential to increase the supply of vaccine by diluting the vaccinia virus of Lister strain to face possible bioterrorism with smallpox was evaluated. Vaccinia-naïve subjects (n=97) were randomized to receive either undiluted or diluted (15, 110) vaccine, and previously vaccinated subjects (n=122) were randomized to receive either undiluted or diluted (110, 130) vaccine. Except two subjects who received 130 diluted vaccine, the vaccination of all subjects was successful clinically. All subjects had significant vaccinia-specific T cell and antibody responses. The diluted vaccine was not associated with decreased local or systemic reactions, lower T cell responses, or higher antibody titers when compared with undiluted vaccine. Here we show the diluted vaccine of Lister strain can be used in vaccinia-naïve subjects and previously vaccinated subjects if viral titer > or =10(8) and 10(7.5) pfu/mL after dilution, respectively. The reactogenicity of vaccinia virus may not be a dose-dependent response.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Variola virus
/
Smallpox Vaccine
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Vaccine
Year:
2006
Document type:
Article