Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin.

Applequist, Steven E; Rollman, Erik; Wareing, Mark D; Lidén, Martin; Rozell, Björn; Hinkula, Jorma; Ljunggren, Hans-Gustaf

Applequist, Steven E; Rollman, Erik; Wareing, Mark D; Lidén, Martin; Rozell, Björn; Hinkula, Jorma; Ljunggren, Hans-Gustaf.

Affiliation

Applequist SE; Center for Infectious Medicine, F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital at Huddinge, Stockholm, Sweden. steapp@mbox.ki.se

J Immunol ; 175(6): 3882-91, 2005 Sep 15.

Article in En | MEDLINE | ID: mdl-16148134

Subject(s)

Flagellin/pharmacology; Immunity, Innate/drug effects; Inflammation/chemically induced; Vaccines, DNA/genetics; Animals; Antigens, Viral/administration & dosage; Antigens, Viral/genetics; Cell Line; Flagellin/administration & dosage; Flagellin/genetics; Genetic Vectors; Humans; Immunity, Cellular/drug effects; Immunoglobulin A/biosynthesis; Immunoglobulin G/biosynthesis; Influenza A virus/immunology; Influenza, Human/prevention & control; Influenza, Human/therapy; Mice; Mice, Inbred C57BL; Nucleocapsid Proteins; Nucleoproteins/administration & dosage; Nucleoproteins/genetics; RNA-Binding Proteins/administration & dosage; RNA-Binding Proteins/genetics; Vaccines, DNA/administration & dosage; Vaccines, DNA/pharmacology; Viral Core Proteins/administration & dosage; Viral Core Proteins/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Vaccines, DNA / Flagellin / Immunity, Innate / Inflammation Limits: Animals / Humans Language: En Journal: J Immunol Year: 2005 Document type: Article Affiliation country: Sweden Country of publication: United States

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