Cytochrome p450 2C inhibition reduces post-ischemic vascular dysfunction.

Hunter, Arwen L; Bai, Ni; Laher, Ismail; Granville, David J

Hunter, Arwen L; Bai, Ni; Laher, Ismail; Granville, David J.

Affiliation

Hunter AL; The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Room 166 Burrard Building, St. Paul's Hospital, University of British Columbia, 1081 Burrard St., Vancouver, British Columbia, Canada, V6Z 1Y6.

Vascul Pharmacol ; 43(4): 213-9, 2005 Oct.

Article in En | MEDLINE | ID: mdl-16150654

Subject(s)

Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors/pharmacology; Ischemia/complications; Steroid 21-Hydroxylase/antagonists & inhibitors; Vascular Diseases/etiology; Vascular Diseases/prevention & control; Animals; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Ethidium/analogs & derivatives; Fluorescent Dyes; Heart/drug effects; In Vitro Techniques; Male; Muscle, Smooth, Vascular/drug effects; Nitric Oxide/metabolism; Nitric Oxide Synthase Type III/metabolism; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species/metabolism; Sulfaphenazole/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Vascular Diseases / Steroid 21-Hydroxylase / Enzyme Inhibitors / Cytochrome P-450 Enzyme Inhibitors / Ischemia Limits: Animals Language: En Journal: Vascul Pharmacol Journal subject: ANGIOLOGIA / FARMACOLOGIA Year: 2005 Document type: Article Country of publication: United States

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