Nicotinamide induces apoptosis and reduces collagen I and pro-inflammatory cytokines expression in rat hepatic stellate cells.

Traister, Alexandra; Breitman, Igal; Bar-Lev, Ella; Zvibel, Isabel; Harel, Avikam; Halpern, Zamir; Oren, Ran

Traister, Alexandra; Breitman, Igal; Bar-Lev, Ella; Zvibel, Isabel; Harel, Avikam; Halpern, Zamir; Oren, Ran.

Affiliation

Traister A; Liver Unit, Gastroenterology Institute, and Tel Aviv, Israel.

Scand J Gastroenterol ; 40(10): 1226-34, 2005 Oct.

Article in En | MEDLINE | ID: mdl-16165703

Subject(s)

Apoptosis/drug effects; Collagen Type I/drug effects; Cytokines/drug effects; Hepatocytes/drug effects; Hepatocytes/metabolism; Niacinamide/pharmacology; Vitamin B Complex/pharmacology; Actins/drug effects; Actins/metabolism; Animals; Blotting, Northern; Blotting, Western; Caspase 3; Caspases/drug effects; Caspases/metabolism; Cell Cycle/drug effects; Cell Line; Cell Proliferation/drug effects; Collagen Type I/biosynthesis; Cyclin D1/drug effects; Cyclin D1/metabolism; Cytokines/biosynthesis; Enzyme Activation/drug effects; Flow Cytometry; Glyceraldehyde-3-Phosphate Dehydrogenases/drug effects; Glyceraldehyde-3-Phosphate Dehydrogenases/metabolism; Hepatocytes/pathology; Immunohistochemistry; Inflammation Mediators/metabolism; Liver Cirrhosis/metabolism; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tissue Inhibitor of Metalloproteinases/drug effects; Tissue Inhibitor of Metalloproteinases/metabolism; Tumor Suppressor Protein p53/drug effects; Tumor Suppressor Protein p53/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Vitamin B Complex / Cytokines / Apoptosis / Niacinamide / Hepatocytes / Collagen Type I Type of study: Prognostic_studies Limits: Animals Language: En Journal: Scand J Gastroenterol Year: 2005 Document type: Article Affiliation country: Israel Country of publication: United kingdom

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