Effect of dexamethasone on postoperative cardiac troponin T production in pediatric cardiac surgery.
Intensive Care Med
; 31(10): 1420-6, 2005 Oct.
Article
in En
| MEDLINE
| ID: mdl-16167129
ABSTRACT
OBJECTIVE:
Pediatric cardiac surgery is associated with a temporary rise in cardiac troponin T (cTnT) during the postoperative period. We examined whether dexamethasone given before cardiopulmonary bypass has myocardial protective effects as assessed by the postoperative production of cTnT. DESIGN ANDSETTING:
Prospective randomized interventional study in the pediatric intensive care unit in a university hospital.INTERVENTIONS:
Patients were randomly allocated to act as controls or receive a single dose of dexamethasone (1 mg/kg) during induction of anesthesia. MEASUREMENTS ANDRESULTS:
cTnT was measured four times postoperatively immediately after admission to the pediatric intensive care unit (PICU) and 8, 15, and 24 h thereafter. The two groups had similar mean cTnT concentrations on PICU admission those receiving dexamethasone 1.85 ng/ml (1.55-2.15) and those not receiving it 2 ng/ml (95% confidence interval 1.56-2.51). Concentrations of cTnT 8 h after admission to the PICU differed significantly after 8 h 1.99 ng/ml (1.53-2.45) in those receiving dexamethasone and 3.08 ng/ml (2.46-3.69) in those not receiving it. After subgroup statistical analysis differences between the two groups remained significant only at 8 h, not those after 15 or 24 h.CONCLUSIONS:
The use of dexamethasone (1 mg/kg) before cardiopulmonary bypass is associated with a brief but significant reduction in postoperative cTnT production. The clinical significance of this effect is unclear.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dexamethasone
/
Troponin T
/
Heart Defects, Congenital
/
Anti-Inflammatory Agents
Type of study:
Clinical_trials
Limits:
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Intensive Care Med
Year:
2005
Document type:
Article
Affiliation country:
Netherlands