Relationship between radiation injury and Alzheimer-related neurodegenerative changes.
Clin Neuropathol
; 24(5): 236-8, 2005.
Article
in En
| MEDLINE
| ID: mdl-16167548
ABSTRACT
The relationship between radiation injury and other neurodegenerative changes such as the formation of neuritic or diffuse plaques and tangles have received little attention in the literature. In the current study, archival tissue was examined from 485 patients with the diagnosis of either a primary or metastatic brain tumor, who had received radiation therapy between the initial and subsequent pathological study (either surgical or autopsy). Of those cases, 20 were identified that also contained cerebral cortex in both specimens. Sections were stained with the modified Bielschowsky technique and immunohistochemical preparations for beta-amyloid. Contrary to previous reports, the present study did not identify neurodegenerative changes typical of Alzheimer's disease as a consequence of radiation therapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Brain Neoplasms
/
Nerve Degeneration
Type of study:
Etiology_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Neuropathol
Year:
2005
Document type:
Article
Affiliation country:
United States