Dexamethasone and recovery of contractile tension after a muscle injury.
Clin Orthop Relat Res
; 439: 235-42, 2005 Oct.
Article
in En
| MEDLINE
| ID: mdl-16205165
ABSTRACT
Muscle strains, frequently the result of a lengthening contraction, sometimes are treated with corticosteroids. We tested whether an injection of dexamethasone administered soon after muscle injury would minimize inflammation and facilitate the recovery of contractile tension. We applied one eccentric contraction on the tibialis anterior of 76 rats, which were randomly assigned to one of three groups sham-injured plus dexamethasone, injured plus vehicle, and injured plus dexamethasone. Electrophysiology, histology, and reverse transcription-polymerase chain reaction were used to study the relation between contractile tension, inflammation, and the expression of inflammatory molecules. The single eccentric contraction led to a reversible muscle injury characterized initially by reduced contractile tension and inflammation. The dexamethasone injection reduced the expression of interleukin-1beta and transforming growth factor-beta1 compared with injured vehicle-injected controls and led to a transient improvement of contractile tension 3 days after the injury. No adverse effects were seen for as much as 3 weeks after the dexamethasone injection. The data indicate that one dose of dexamethasone administered soon after muscle strain may facilitate recovery of contractile tension without causing major adverse consequences in this experimental model.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sprains and Strains
/
Dexamethasone
/
Muscle, Skeletal
/
Anti-Inflammatory Agents
/
Muscle Contraction
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Clin Orthop Relat Res
Year:
2005
Document type:
Article
Affiliation country:
United States