An oral carcinogenicity and toxicity study of senna (Tinnevelly senna fruits) in the rat.

Mitchell, J M; Mengs, U; McPherson, S; Zijlstra, J; Dettmar, P; Gregson, R; Tigner, J C

Mitchell, J M; Mengs, U; McPherson, S; Zijlstra, J; Dettmar, P; Gregson, R; Tigner, J C.

Affiliation

Mitchell JM; Purdue Pharma, Ardsley, NY, USA.

Arch Toxicol ; 80(1): 34-44, 2006 Jan.

Article in En | MEDLINE | ID: mdl-16205914

Subject(s)

Cathartics/toxicity; Intestines/drug effects; Kidney/drug effects; Senna Extract/toxicity; Senna Plant; Administration, Oral; Animals; Body Weight/drug effects; Carcinogenicity Tests; Cathartics/administration & dosage; Cathartics/pharmacokinetics; Drinking/drug effects; Fruit; Humans; Intestines/pathology; Intubation, Gastrointestinal; Kidney/pathology; Male; Maximum Tolerated Dose; Rats; Rats, Sprague-Dawley; Senna Extract/administration & dosage; Senna Extract/pharmacokinetics; Toxicity Tests, Chronic

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Collection: 01-internacional Database: MEDLINE Main subject: Senna Extract / Cathartics / Senna Plant / Intestines / Kidney Limits: Animals / Humans / Male Language: En Journal: Arch Toxicol Year: 2006 Document type: Article Affiliation country: United States Country of publication: Germany

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