A novel approach to perform metabolite screening during the quantitative LC-MS/MS analyses of in vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer.

Shou, Wilson Z; Magis, Lisa; Li, Austin C; Naidong, Weng; Bryant, Matthew S

Shou, Wilson Z; Magis, Lisa; Li, Austin C; Naidong, Weng; Bryant, Matthew S.

Affiliation

Shou WZ; Covance Laboratories Inc., 3301 Kinsman Boulevard, Madison, Wisconsin 53704, USA. wilson.shou@covance.com

J Mass Spectrom ; 40(10): 1347-56, 2005 Oct.

Article in En | MEDLINE | ID: mdl-16206149

Subject(s)

Biotransformation; Drug Evaluation, Preclinical/methods; Microsomes, Liver/metabolism; Pharmaceutical Preparations/metabolism; Spectrometry, Mass, Electrospray Ionization/methods; Humans; In Vitro Techniques

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Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Pharmaceutical Preparations / Biotransformation / Spectrometry, Mass, Electrospray Ionization / Drug Evaluation, Preclinical Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Journal: J Mass Spectrom Year: 2005 Document type: Article Affiliation country: United States

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