Simulating chemotherapeutic schemes in the individualized treatment context: the paradigm of glioblastoma multiforme treated by temozolomide in vivo.
Comput Biol Med
; 36(11): 1216-34, 2006 Nov.
Article
in En
| MEDLINE
| ID: mdl-16207487
ABSTRACT
A novel patient individualized, spatiotemporal Monte Carlo simulation model of tumor response to chemotherapeutic schemes in vivo is presented. Treatment of glioblastoma multiforme by temozolomide is considered as a paradigm. The model is based on the patient's imaging, histopathologic and genetic data. A discretization mesh is superimposed upon the anatomical region of interest and within each geometrical cell of the mesh the most prominent biological "laws" (cell cycling, apoptosis, etc.) in conjunction with pharmacokinetics and pharmacodynamics information are applied. A good qualitative agreement of the model's predictions with clinical experience supports the applicability of the approach to chemotherapy optimization.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Therapy, Computer-Assisted
/
Brain Neoplasms
/
Cell Cycle
/
Cell Division
/
Apoptosis
/
Glioblastoma
/
Antineoplastic Agents, Alkylating
/
Dacarbazine
Type of study:
Prognostic_studies
/
Qualitative_research
Limits:
Humans
Language:
En
Journal:
Comput Biol Med
Year:
2006
Document type:
Article
Affiliation country:
Greece