Novel compounds that interact with both leukotriene B4 receptors and vanilloid TRPV1 receptors.

McHugh, Douglas; McMaster, R Shannon; Pertwee, Roger G; Roy, Sucharita; Mahadevan, Anu; Razdan, Raj K; Ross, Ruth A

McHugh, Douglas; McMaster, R Shannon; Pertwee, Roger G; Roy, Sucharita; Mahadevan, Anu; Razdan, Raj K; Ross, Ruth A.

Affiliation

McHugh D; Institute of Medical Sciences, University of Aberdeen, Scotland.

J Pharmacol Exp Ther ; 316(2): 955-65, 2006 Feb.

Article in En | MEDLINE | ID: mdl-16207832

Subject(s)

Leukotriene B4/analogs & derivatives; Leukotriene B4/pharmacology; Receptors, Leukotriene B4/metabolism; TRPV Cation Channels/metabolism; Animals; CHO Cells; Calcium/metabolism; Chemotaxis, Leukocyte/drug effects; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Lung/drug effects; Lung/metabolism; Molecular Structure; Neurons/drug effects; Neurons/metabolism; Neutrophils/drug effects; Neutrophils/metabolism; Rats; Rats, Sprague-Dawley; Recombinant Proteins/metabolism; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Leukotriene B4 / Leukotriene B4 / TRPV Cation Channels Limits: Animals / Humans Language: En Journal: J Pharmacol Exp Ther Year: 2006 Document type: Article Affiliation country: United kingdom Country of publication: United States

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