Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad.

Palozza, P; Sheriff, A; Serini, S; Boninsegna, A; Maggiano, N; Ranelletti, F O; Calviello, G; Cittadini, A

Palozza, P; Sheriff, A; Serini, S; Boninsegna, A; Maggiano, N; Ranelletti, F O; Calviello, G; Cittadini, A.

Affiliation

Palozza P; Institute of General Pathology, Catholic University, Rome, Italy. p.palozza@rm.unicatt.it

Apoptosis ; 10(6): 1445-56, 2005 Dec.

Article in En | MEDLINE | ID: mdl-16215689

Subject(s)

Apoptosis/drug effects; Carotenoids/pharmacology; Cyclin D1/metabolism; Fibroblasts/cytology; Proto-Oncogene Proteins c-akt/metabolism; Smoke/adverse effects; bcl-Associated Death Protein/metabolism; 8-Hydroxy-2'-Deoxyguanosine; Animals; Blotting, Western; Cell Cycle/drug effects; Cell Line, Transformed; Cell Proliferation/drug effects; Cyclooxygenase 2/metabolism; Deoxyguanosine/analogs & derivatives; Deoxyguanosine/metabolism; Down-Regulation/drug effects; Fibroblasts/drug effects; Fibroblasts/enzymology; Lycopene; Phosphoproteins/metabolism; Rats; Smoking/adverse effects; Nicotiana; Tumor Suppressor Protein p53/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Smoke / Carotenoids / Apoptosis / Cyclin D1 / Proto-Oncogene Proteins c-akt / Bcl-Associated Death Protein / Fibroblasts Limits: Animals Language: En Journal: Apoptosis Year: 2005 Document type: Article Affiliation country: Italy

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