Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins.

O'Neill, Paul M; Rawe, Sarah L; Borstnik, Kristina; Miller, Alison; Ward, Stephen A; Bray, Patrick G; Davies, Jill; Oh, Chang Ho; Posner, Gary H

O'Neill, Paul M; Rawe, Sarah L; Borstnik, Kristina; Miller, Alison; Ward, Stephen A; Bray, Patrick G; Davies, Jill; Oh, Chang Ho; Posner, Gary H.

Affiliation

O'Neill PM; Department of Chemistry, University of Liverpool, The Robert Robinson Laboratories, Oxford Street, Liverpool, L69 7ZD, UK. p.m.oneill01@liv.ac.uk

Chembiochem ; 6(11): 2048-54, 2005 Nov.

Article in En | MEDLINE | ID: mdl-16222725

Subject(s)

Antimalarials/pharmacology; Artemisinins/pharmacology; Heterocyclic Compounds/pharmacology; Plasmodium falciparum/drug effects; Animals; Antimalarials/chemical synthesis; Antimalarials/chemistry; Artemisinins/metabolism; Drug Design; Heterocyclic Compounds/chemical synthesis; Heterocyclic Compounds/chemistry; Inhibitory Concentration 50; Molecular Structure; Parasitic Sensitivity Tests; Stereoisomerism

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Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Artemisinins / Heterocyclic Compounds / Antimalarials Limits: Animals Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2005 Document type: Article Affiliation country: United kingdom Country of publication: Germany

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