The biology of breast tumor progression. Acquisition of hormone independence and resistance to cytotoxic drugs.
Acta Oncol
; 31(2): 115-23, 1992.
Article
in En
| MEDLINE
| ID: mdl-1622625
ABSTRACT
Many breast tumors appear to follow a predictable clinical pattern, being initially responsive to endocrine therapy and to cytotoxic chemotherapy but ultimately exhibiting a phenotype resistant to both modalities. Using the MCF-7 human breast cancer cell line as an example of an 'early' phenotype (estrogen and progesterone receptor positive, steroid responsive, low metastatic potential), we have isolated and characterized a series of hormone-independent but hormone-responsive variants (MIII and MCF7/LCC1). However, these variants remain responsive to both antiestrogens and cytotoxic drugs (methotrexate and colchicine). MIII and MCF7/LCC1 cells appear to mimic some of the critical aspects of the early progression to a more aggressive phenotype. An examination of the phenotype of these cells suggests that some hormone-independent breast cancer cells are derived from hormone-dependent parental cells. The development of a hormone-independent phenotype can arise independently of acquisition of a cytotoxic drug resistant phenotype.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Drug Resistance
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Acta Oncol
Journal subject:
NEOPLASIAS
Year:
1992
Document type:
Article