Glomerulopathy with renal tubular oxalosis in Japanese rock ptarmigan (Lagopus mutus).

ABSTRACT

Seven adult Japanese rock ptarmigan (Lagopus mutus) that died on a rearing farm and appeared to have suffered from glomerulopathy with renal tubular oxalosis were examined pathologically. Macroscopically, the kidneys showed enlargement of varying degrees. Histologically, the precipitation of a fibril-like substance in the mesangial area of the renal glomeruli was the most important and common lesion seen in the kidney. Calcification of glomeruli was observed in severe cases. In addition, oxalate precipitation in the lumen of the renal tubules was associated with glomerular lesions. The primary renal lesion may have been glomerulonephropathy, which was subsequently associated with tubular oxalosis as the secondary renal lesion.