Glycogen phosphorylase inhibitors: a free energy perturbation analysis of glucopyranose spirohydantoin analogues.

Archontis, G; Watson, K A; Xie, Q; Andreou, G; Chrysina, E D; Zographos, S E; Oikonomakos, N G; Karplus, M

Archontis, G; Watson, K A; Xie, Q; Andreou, G; Chrysina, E D; Zographos, S E; Oikonomakos, N G; Karplus, M.

Affiliation

Archontis G; Department of Physics, University of Cyprus, Cyprus. archonti@ucy.ac.cy

Proteins ; 61(4): 984-98, 2005 Dec 01.

Article in En | MEDLINE | ID: mdl-16245298

Subject(s)

Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Glucose/analogs & derivatives; Glycogen Phosphorylase/antagonists & inhibitors; Hydantoins/chemistry; Computer Simulation; Crystallography, X-Ray; Drug Design; Glucose/chemistry; Glucose/pharmacology; Hydantoins/pharmacology; Kinetics; Ligands; Phosphorylation; Structure-Activity Relationship; Thermodynamics

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Collection: 01-internacional Database: MEDLINE Main subject: Glycogen Phosphorylase / Enzyme Inhibitors / Glucose / Hydantoins Language: En Journal: Proteins Journal subject: BIOQUIMICA Year: 2005 Document type: Article Affiliation country: Cyprus Country of publication: United States

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