Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead.
Bioorg Med Chem Lett
; 16(1): 36-9, 2006 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-16246553
ABSTRACT
Substrate-based tetrapeptide inhibitors with various warheads were designed, synthesized, and evaluated against the Dengue virus NS3 protease. Effective inhibition was achieved by peptide inhibitors with electrophilic warheads such as aldehyde, trifluoromethyl ketone, and boronic acid. A boronic acid has the highest affinity, exhibiting a K(i) of 43 nM.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Protease Inhibitors
/
Drug Design
/
Chemistry, Pharmaceutical
/
Viral Nonstructural Proteins
/
Dengue Virus
Type of study:
Prognostic_studies
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2006
Document type:
Article
Affiliation country:
Singapore