Evaluation of the carcinogenic potential of clofibrate in the p53+/- mouse.

Torrey, Carla E; Campbell, James A; Hoivik, Debie J; Miller, Richard T; Allen, Jane S; Mann, Peter C; Selinger, Krzysztof; Rickert, Douglas; Savina, Paul M; Santostefano, Michael J

Torrey, Carla E; Campbell, James A; Hoivik, Debie J; Miller, Richard T; Allen, Jane S; Mann, Peter C; Selinger, Krzysztof; Rickert, Douglas; Savina, Paul M; Santostefano, Michael J.

Affiliation

Torrey CE; GlaxoSmithKline, Safety Assessment, Research Triangle Park, North Carolina 27709, USA.

Int J Toxicol ; 24(5): 289-99, 2005.

Article in En | MEDLINE | ID: mdl-16257849

Subject(s)

Clofibrate/toxicity; Genes, p53; Peroxisome Proliferators/toxicity; Administration, Oral; Adrenal Glands/pathology; Animals; Carcinogenicity Tests; Clofibrate/administration & dosage; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreas/pathology; Peroxisome Proliferators/administration & dosage; Prostate/pathology; Risk Assessment; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Genes, p53 / Clofibrate / Peroxisome Proliferators Type of study: Etiology_studies / Risk_factors_studies Limits: Animals Language: En Journal: Int J Toxicol Journal subject: TOXICOLOGIA Year: 2005 Document type: Article Affiliation country: United States

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