Ghrelin cell density in the gastrointestinal tracts of animal models of human diabetes.
Histol Histopathol
; 21(1): 1-5, 2006 01.
Article
in En
| MEDLINE
| ID: mdl-16267781
ABSTRACT
Ghrelin cell density in the gastrointestinal tract of animal models of human diabetes type 1 and 2 was investigated. The animals used were non-obese diabetic (NOD) mice and obese diabetic mice. Ghrelin cells were detected by immunohistochemistry and quantified by computerized image analysis. Ghrelin-immunoreactive cells were detected in all animals studied. They were abundant in the oxyntic mucosa, patchy and few in the duodenum and rare in the colon. The density of ghrelin-immunoreactive cells decreased in diabetic, pre-diabetic NOD mice and in obese diabetic mice as compared to controls, though not statistically significant. It was concluded that the reduced density of ghrelin-immunoreactive cells in animal models of human diabetes type 1 and 2 might explain the slow gastric emptying and slow intestinal transit found in diabetes gastroenteropathy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Hormones
/
Diabetes Mellitus, Type 1
/
Diabetes Mellitus, Type 2
/
Disease Models, Animal
/
Gastric Mucosa
/
Intestinal Mucosa
Limits:
Animals
Language:
En
Journal:
Histol Histopathol
Journal subject:
HISTOLOGIA
/
PATOLOGIA
Year:
2006
Document type:
Article
Affiliation country:
Sweden