Probing the effect of point mutations at protein-protein interfaces with free energy calculations.

Almlöf, Martin; Aqvist, Johan; Smalås, Arne O; Brandsdal, Bjørn O

Almlöf, Martin; Aqvist, Johan; Smalås, Arne O; Brandsdal, Bjørn O.

Affiliation

Almlöf M; Department of Cell and Molecular Biology, Uppsala University, Biomedical Centre, Uppsala, Sweden.

Biophys J ; 90(2): 433-42, 2006 Jan 15.

Article in En | MEDLINE | ID: mdl-16272444

Subject(s)

Chymotrypsin/chemistry; Chymotrypsin/genetics; Pancreatic Elastase/chemistry; Point Mutation; Protein Interaction Mapping; Animals; Binding Sites; Cattle; Crystallography, X-Ray; Entropy; Humans; Leukocyte Elastase/chemistry; Ligands; Models, Molecular; Models, Theoretical; Mutation; Protein Binding; Protein Structure, Tertiary; Sensitivity and Specificity; Static Electricity; Thermodynamics; Trypsin/chemistry; Trypsin Inhibitor, Kazal Pancreatic/chemistry; Turkeys; X-Rays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chymotrypsin / Pancreatic Elastase / Point Mutation / Protein Interaction Mapping Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Biophys J Year: 2006 Document type: Article Affiliation country: Sweden Country of publication: United States

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