Benzophenone-based farnesyltransferase inhibitors with high activity against Trypanosoma cruzi.

Esteva, Mónica I; Kettler, Katja; Maidana, Cristina; Fichera, Laura; Ruiz, Andrés M; Bontempi, Esteban J; Andersson, Björn; Dahse, Hans-Martin; Haebel, Peter; Ortmann, Regina; Klebe, Gerhard; Schlitzer, Martin

Esteva, Mónica I; Kettler, Katja; Maidana, Cristina; Fichera, Laura; Ruiz, Andrés M; Bontempi, Esteban J; Andersson, Björn; Dahse, Hans-Martin; Haebel, Peter; Ortmann, Regina; Klebe, Gerhard; Schlitzer, Martin.

Affiliation

Esteva MI; Instituto Nacional de Parasitología Dr. M. Fatala Chabén, A.N.L.I.S., Dr. Carlos G. Malbrán, 1063 Buenos Aires, Argentina.

J Med Chem ; 48(23): 7186-91, 2005 Nov 17.

Article in En | MEDLINE | ID: mdl-16279776

Subject(s)

Benzophenones/chemical synthesis; Farnesyltranstransferase/antagonists & inhibitors; Trypanocidal Agents/chemical synthesis; Trypanosoma cruzi/drug effects; Animals; Benzophenones/chemistry; Benzophenones/pharmacology; Chagas Disease/mortality; Chagas Disease/parasitology; Farnesyltranstransferase/chemistry; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Protein Subunits/chemistry; Sequence Homology, Amino Acid; Structure-Activity Relationship; Trypanocidal Agents/chemistry; Trypanocidal Agents/pharmacology; Trypanosoma cruzi/enzymology

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Collection: 01-internacional Database: MEDLINE Main subject: Trypanocidal Agents / Trypanosoma cruzi / Benzophenones / Farnesyltranstransferase Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2005 Document type: Article Affiliation country: Argentina

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