Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer.

Greco, O; Joiner, M C; Doleh, A; Powell, A D; Hillman, G G; Scott, S D

Greco, O; Joiner, M C; Doleh, A; Powell, A D; Hillman, G G; Scott, S D.

Affiliation

Greco O; Department of Radiation Oncology, Wayne State University and Karmanos Cancer Institute, Hudson Webber CRC, Detroit, MI, USA. o.greco@sheffield.ac.uk

Gene Ther ; 13(3): 206-15, 2006 Feb.

Article in En | MEDLINE | ID: mdl-16307003

Subject(s)

Adenoviridae/genetics; Genetic Therapy/methods; Genetic Vectors/genetics; Neoplasms/therapy; Oncolytic Virotherapy/methods; Adenocarcinoma/pathology; Adenocarcinoma/therapy; Animals; Antiviral Agents/therapeutic use; Brain Neoplasms/pathology; Brain Neoplasms/therapy; Breast Neoplasms/pathology; Breast Neoplasms/therapy; Cell Death; Cell Hypoxia; Combined Modality Therapy; Early Growth Response Protein 1/genetics; Erythropoietin/genetics; Ganciclovir/therapeutic use; Gene Expression Regulation, Neoplastic; Genes, Switch; Genes, Transgenic, Suicide; Genetic Engineering/methods; Genetic Vectors/administration & dosage; Genetic Vectors/radiation effects; Glioma/pathology; Glioma/therapy; Humans; Mice; Mice, Nude; Neoplasms/pathology; Promoter Regions, Genetic; Simplexvirus/enzymology; Thymidine Kinase/biosynthesis; Thymidine Kinase/metabolism; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Adenoviridae / Oncolytic Virotherapy / Genetic Vectors / Neoplasms Type of study: Prognostic_studies Language: En Journal: Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 2006 Document type: Article Affiliation country: United States

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